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Laser LabCorp New US Patent for Laser Technology for The Treatment Of Mucositis Using Photobiomodulation.

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Boca Raton, FL – April 28, 2024 – Mucositis is a complication of cytotoxic cancer treat­ments, such as chemotherapy and radiation. As a result of such highly toxic cancer treatments, the rapidly dividing epithelial cells of the gastro-intestinal cells can break down. 

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 This leaves the mucosaL lining susceptible to many classes of damage, for instance ulceration and infection. Of note, the 25 mucosa virtually lines every organ in the body from the gastrointestinal tract to the pulmonary tree. This point is important given that we are presenting a novel treatment that has the potential to treat any mucosa! lining affected by cancer treatment. 

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Of all areas that can be affected by Cytotoxic treatment, the oral cavity including the cheeks, lips, gums, inner cavity, and tonsillar region-all of the soft tissues are the most common locations for mucositis. Oral Mucositis is likely the most common, debilitating complication of cancer treat- 35 ments, especially chemotherapy and radiation. Symptoms and sequelae typical of oral mucositis include red, shiny, or swollen mouth and gums, blood in the mouth, sores in the mouth or on the gums or tongue, soreness or pain in the mouth or throat, difficulty swallowing or talking, and xero- 40 stomia, mild burning, or pain when eating food. Further­more, soft, whitish patches or pus in the mouth or on the tongue are frequently seen in addition to increased mucus or thickened saliva in the mouth.

 

In some cases, oral mucositis presents in an extreme form called confluent mucositis, in which case the mucous membrane of the patient's entire mouth and tongue can be coated by a white mucus coating that is up to a millimeter thick, making it nearly impossible for the patient to eat food. It has a significant effect on the patient's quality of life and can be dose-limiting with respect 50 to the cancer treatment, a highly undesirable consequence of mucositis when the cancer team is trying to adequately treat a malignancy. 

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Treatment options today are limited once mucositis sets in. Patients are usually given pain medication and/or anti- 55 septic mouthwash. Beyond that, there is not much doctors can do for the painful condition that, at advanced stages, can inhibit a patient's ability to eat and speak. 

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More recently, the use of photobiomodulation (PBM) has been introduced to treat mucositis. PBM is a light therapy in 60 which laser light or light emitting diode (LED) light is applied to tissue to improve tissue repair, reduce pain and inflammation. PBM (also termed low laser light therapy (LLLT) functions according to first law in photochemistry [Grotthuss-Draper law].

 

According to this law, light must be 65 absorbed by a chemical substance in order to generate photochemical reaction. In PBM, that chemical substance is Treatment options today are limited once mucositis sets in. Patients are usually given pain medication and/or anti- septic mouthwash.

 

Beyond that, there is not much doctors can do for the painful condition that, at advanced stages, can inhibit a patient's ability to eat and speak. More recently, the use of photobiomodulation (PBM) has been introduced to treat mucositis. PBM is a light therapy in 60 which laser light or light emitting diode (LED) light is applied to tissue to improve tissue repair, reduce pain and inflammation.

 

PBM (also termed low laser light therapy (LLLT) functions according to first law in photochemistry [Grotthuss-Draper law]. According to this law, light must be 65 absorbed by a chemical substance in order to generate photochemical reaction. In PBM, that chemical substance is represented by the respiratory enzyme Cytochrome C oxi­dase, which is involved in the electron transport chain that occurs in the mitochondria of cells.

 

Mitochondria are the "powerhouse" of the cell, the subcellular organelle in which the TCA cycle takes place, allowing an oxygen molecule to be converted into 46 ATP ( adenosine triphosphate ), the form of energy that is usable by the human body. It is believed that low-level radiation is absorbed by intracellular photorecep­tors in the membrane of the mitochondria.

 

The effects  include a reduction in pain due to increased endorphins, reduction in inflammation via reduction in interleukin-I and C-reactive protein and tissue healing effects as a result of increased neovascularization and macrophage activity.

 

While PBM therapy is promising, Applicant recognizes shortcomings in current approaches. For example, current approaches tend to use bulky, desktop units, which emit a diffused beam and require contact with the tissue being treated. Such contact can cause irritation (e.g., on ulcers and other open sores) and raises sterilization concerns. Accord- 20 ingly, Applicant identifies the need for a maneuverable, handheld device, which need not contact with the tissue being treated. The present invention fulfills this need, among others. 

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This patent covers the method for treating an oral cavity malady of a patient, comprising: applying a spot of a laser beam to a target area around the oral cavity, said laser beam having a wavelength of about 800 to 840 nm and a power of between 1000 and 4000 mW, and wherein said spot has a spot size of about 1 to about 10 mm; and moving said spot on said target area for a treatment time sufficient to deliver a dose of about 0.5 to about 30 J/cm2 to said target area.

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Those seeking further information can reference US Pat. No. 11,925,816 B2

For additional information, please contact Laser LabCorps CEO Bradley Schoengood at Brad@laserlabcorp.com

 

About Laser LabCorp 
At Laser LabCorp, we develop new solutions that give medical professionals the power to adapt, evolve, and stay at the forefront of the field so that they can deliver true patient satisfaction. Ideating, exploring, designing, testing, and developing new solutions is the foundation of our process that has created truly one-of-a-kind devices.In 2014, Laser LabCorp was founded —and that original spirit of innovation drives the advancements we pioneer in medical lasers and diagnsotics imaging practices globally. At Laser LabCorp, our philosophy is simple—define the forefront of medical lasers with devices that are engineered to deliver the highest level of performance, safety, and efficacy. For more information about Laser LabCorp, please visit www.laserlabcorp.com.